So I tried to be smart, uninstalled Microsoft .NET Framework from Add or Remove Programs and it was successful. I encountered another problem which is I can’t get .NET Framework to install no matter what I did. Now I don’t even have any version of .NET Framework installed on my computer which is even worst than before. Last time I could at least run other .NET Framework applications except one of it but now none at all!

I remembered finding Aaron Stebner’s WebLog on how to manually cleanup the .NET Framework but I still couldn’t get it fixed. In the end I ended up reformatting my hard drive and reinstall Windows just because I couldn’t get .NET Framework installed again (I had some .NET Framework apps that I urgently need to use). Lucky you all now, if you had the same problem, Aaron Stebner has created a cleanup tool which automates removing Microsoft .NET Framework 1.0, 1.1, 2.0, 3.0 and 3.5.

Aaron Stebner’s .NET Framework Setup Cleanup Utility contains support for automatically cleaning up the .NET Framework 1.0, the .NET Framework 1.1, the .NET Framework 2.0, the .NET Framework 3.0 and the .NET Framework 3.5.

This tool automates the manual cleanup steps for the .NET Framework 2.0 that Aaron Stebner posted a while ago (I went through the manual steps before and it was not easy). These steps have helped solve most of the known .NET Framework 2.0 beta uninstall issues that Aaron know of. In addition, the tool can be useful to return your system to a known (relatively clean) state in case you run into any .NET Framework 2.0 installation failures so that you can try to install again.

The updated version of the cleanup tool contains options to clean up the .NET Framework 1.0, 1.1, 2.0, 3.0 and 3.5 separately and all versions simultaneously in a single step. The cleanup tool contains logic so that if it is run on an OS version that includes the .NET Framework as an OS component, it will not offer the option to clean it up. This means that running the cleanup tool on Windows XP Media Center Edition or Tablet PC Edition will not offer the option to clean up the .NET Framework 1.0, running it on Windows Server 2003 will not offer the option to clean up the .NET Framework 1.1 and running it on Windows Vista will not offer the option to clean up the .NET Framework 2.0 or the .NET Framework 3.0.

The .NET Framework cleanup tool is very easy to use. Just download, extract and run cleanup_tool.exe. Select the version of .NET Framework that you want to cleanup and click the “Cleanup Now” button. The cleanup process takes a while, so be patient and don’t close the cleanup tool or restart your computer.

This tool is designed as a last resort for cases where install, uninstall or repair did not succeed for unusual reasons. It is not intended as a substitute for the standard uninstall procedure. You should try to perform an uninstall from Add/Remove Programs before using this cleanup tool. The last time I uninstalled .NET Framework was disastrous, so ONLY uninstall .NET Framework when you have no other choice.

[ Download .NET Framework Setup Cleanup Utility ]

Technorati Tags: cleanup, uninstall, remove, .net, framework

When Steve Jobs convened the “Let’s Rock” event to unveil the new iPod Nano in September, he made a point of whetting our appetites for premium in-ear headphones with remote and mic that were said, at the time, to be shipping in October. It’s now December and the Apple website still says “Coming Soon.”

Apple engineers were ordered to revise the design, which required Apple’s overseas contractors to retool their manufacturing process, resulting in the extended delay, according to sources cited by MacBloz on Monday.

The premium headphones, slated to retail for $79, are intended to compete with high-end audiophile headsets costing two and three times that amount from the likes of Bose and Sony, and according to the MacBlogz sources, that standard has not yet been achieved. On the other hand, it should be premature to rule out a splashy marketing deployment of the eagerly anticipated headphones just in time for last minute holiday shopping.

Via MacBlogz.

For Yahoo, Spears wasn't the only pop-culture icon in Yahoo's top 10 searches. Also on the list were Miley Cyrus at No. 4, Jessica Alba at No. 6, Lindsay Lohan at No. 7, and Angelina Jolie at No. 9.

Apparently a lot of people are curious about World Wrestling Entertainment, because WWE was No. 2. The online game RuneScape was No. 5, anime series Naruto was No. 7, and American Idol finished in 10th place on Yahoo's list.

Yahoo also broke down searches for various other subjects. For economic searches, the top 10 list started with IRS stimulus checks, then followed with oil prices, gold prices, gas prices, Dow Jones, Sallie Mae, stock market, AIG, foreclosures, and debt consolidation. The list reveals that people use general-purpose searches for everything ranging from how-to advice to the latest news.

In the people of politics, President-elect Barack Obama led the list. Next came Sarah Palin, John McCain, Hillary Clinton, George Bush, Ron Paul, John Edwards, Mike Huckabee, Arnold Schwarzenegger, and Mitt Romney.

AOL also shared its top search terms for 2008, though it didn't break out overall terms.

Ask.com also spotlighted popular 2008 searches, and has a few variations on the standard search categories. Its top questions are as follows:

1. How do I get pregnant?
2. How do I lose weight?
3. How do I write a resume?
4. How much is minimum wage?
5. How much is my car worth?
6. How do I change my name?
7. What is the meaning of life?
8. How do I register to vote?
9. Why is the sky blue?
10. How do I download videos?

And since Ask.com bought Dictionary.com earlier this year, it's releasing top search terms for that site. People's vocabulary expansion efforts concentrated on these terms: maverick, socialism, economy, recession, radical, cyclone, solace, realtor, environment, and potholes.

Apparently Google, which has shared search trends on its annual Zeitgeist list since 2001, didn't get the memo to release its results Monday, but expect it to cough up some new results soon--and, I hope, some of the accompanying graphs.

The alleged problem: The new transmission method uses a channel currently only employed by a handful of applications, like gaming and VoiP. With P2P traffic flooding that transmission line, users' Skype calls or World of Warcraft sessions could get interrupted amidst the P2P noise, the Register supposes.

Hogwash, says BitTorrent. The company tells the Industry Standard it's trying to implement a "performance neutral" change intended to reduce network congestion. (You can follow the technical debate in greater detail at Slashdot.)

So what will happen? Internet providers don't have the option of blocking BitTorrent traffic: Comcast (CMCSA) tried that once and the FCC pressured them to stop. (And the incoming Obama administration seems even less disposed to Internet filtering/blocking than the current one.) That leaves another option: more download caps for bandwidth hogs, which Comcast has already rolled out, and other providers are testing.

See Also:
Comcast's Diet For Bandwidth Hogs: A 20-Minute Timeout
Comcast, Slapped By FCC, Expands Testing New Tech To Slow Down Your Internet

Could it be that MySpace profiles aren’t all bad? You be the judge.

A Fine Frenzy - This artist has been high in the charts for quite some time, and her page, courtesy of BandSpaces.com, happened to make it as the first in our musical roundup. As you can see, it’s no wonder why.

Joss Stone - It’s all about placement and graphics. One glance down the artist’s page and it’s clear that the standard layout can be warped with some nice colorful touches. This page is a winner.

Shine - You can keep your page looking segmented if you like, but it doesn’t have to be boring. Sweep the page with images and buttons in the right places and you’ve got yourself a rockin’ MySpace destination.

MyNameIsAugust - Delivered by OutLoudMarketing, the page for August looks fairly ordinary in comparison with the items above, but it still manages to please.

Valerie Nicole - Tidy and neat, this isn’t as in-your-face as some of the others, but it’s still a sight for sore eyes - of which there are plenty across the wide world of MySpace.

Underhills - Though the silver-colored music player does feel a little clunky amid the wallpaper, the complete ensemble is nothing short of fantastic. It’s one of those pages bound to elicit an “I wish that had been mine” kind of critique from visitors.

Airlines - Let’s face it. Good promotional media from bands can mean great publicity. (Books are judged by their covers, in other words.) Which is why the MySpace page for The Airlines, another invention of BandSpaces, lands on this list. It gives the visitor a clear impression that they can make equally kick-ass without breaking the bank.

Lady Sovereign - I’ve been somewhat familiar with Lady Sovereign’s songbook for several seasons now, and the sharp color contrast of her MySpace page is befitting of the musical experience she delivers. Very billboard-esque, this one is.

Stereo Transmitted Disease - If you want to take things a little musica obscura in terms of your band name and bio and things, the page assembled for STD sets a good example. It’s a kind of hodgepodge, wrapped into an easily digestible square.

Man Like Machine - Lots of white space but still fun and playful, Man Like Machine is a music page, but gets marked in the Just Plain Pretty category just the same.

We Are Tokyo - This design is white and red in a way reminiscent of staple colors commanded by The White Stripes. Which is fine by us, because We Are Tokyo pull it off quite well.

Mia Sable - This is a winner in so many ways. Done up with just the right amount of glitz and glamour to make it stand out from the crowd, Mia Sable’s MySpace page is nothing short of fantastic. If this doesn’t make you envious, few others will.

The Academy Is - Having your band name plastered across nearly the full top fold of your MySpace page may not such a bad thing, so long as everything else looks proper. And it does!

Censura - Put your name and music front and center and leave the rest for window dressing. This one is not only beautiful. The geography of it makes it worthwhile to emulate.

The Midway State - Another boxy beaut, the page for The Midway State is impressive for its elegant design and its translucent features.

Race the Sun - This one’s simply a gem to look at. Loading the page takes some time, and some things make seem out of place, but heck if this isn’t one of the most image-enhanced pages on the network.

Cambria Detken - An extraordinary piece of work, the profile for Cambria Detken is one of the best. It makes good use of white space like and wraps it up in butterflies and flowers with plenty of green to go around.

Mr North - Oh what some motion graphics can do. The idea here is to splash the page. The paint job is entertaining. The features are all there. Altogether, it’s an engaging place to be. Which is the point.

Rented Mule - One of the more plainly drawn pages, Rented Mule Jazz is something that lots of folks could take cues from without a degree in design. Easy does it.

Helena Jesse - The lesson here: put heavy emphasis on your header and you’ll grab some attention. The rest of the page is fairly ordinary, but perhaps we’re in store for further enhancements.

Goodnight Caulfield - Akin to the Mia Sable page, albeit made for a four-piece group, Goodnight Caulfield’s profile is so polished that you start to question whether anything is wrong with it. Very little, it turns out!

Gonna Get Got - What a treat. Name emblazoned in white across the top, great graphical touches the entire length of the page, music placed front and center. What else can you ask for? Add another URL to the winner’s circle.

Zone Music - It would be quite basic without that collage to the right of the music player, but if that’s what makes this gem, then so be it. The page is superb with all facets included.

Paul Cullen - So well done, yet not excessively so. It befits the artist, for sure. Which is how it should be, wouldn’t you agree? Out Loud is responsible for making this page happen.

Scott Philipp - That’s Scott Philipp and the StoneBaby Band, to be precise. The contrast of colors make seem a little unusual to some. Black and soft gold are quite a juxtaposition to make. But stick around for a moment and you’ll why we picked it as one of the best.

Ricky Martin - Alright, you may like the guy’s music, or you may not. But one thing is certain. His MySpace page is a great one. It’s refined and easy to navigate without being imposing in any way.

The Stooges - The page rocks. Enough said.

Lenny Kravitz - If you haven’t seen the place before, you will be surprised. The choice of  photo slideshow and background and menu layout and profile componentry, there’s something for most any MySpace page designer to be fond of.

The Almost - Bold and soft all in one page, it’s an interesting thing to look at. It’s colorful but not too much so. It’s very clearly and basically designed, which makes it seem borderline amateurish. So it get a nod.

JMR Productions - We’ll toss this in simply for spice. It’s brash and at the same time fairly plainspoken. It’s great.

Brianna Sage - One of the better sites to make smart use of white space, the profile constructed by Out Loud for Brianna Sage is really well done. The design firm has certainly shown a consistency across many of its creations that it’s hard to imagine anything dreadful coming from its assembly line. A complementary applause is deserved.

Teddy Geiger - It’s not immediately apparent that this is a great design, but give it a moment, we say. It’s the right mix of photography and fringe edits that give it a place on this map.

Ken Hyland - One of the more clean and collected profiles of this broad bunch, the profile for Ken Hyland has professionalism written all over it.

Coldplay - Are broad brush strokes enough to make a MySpace page attractive? We think so. Oh, and there are plenty of little quirks and uniquities to satisfy most folks. (Just as long as they’re noticed.)

Led Zeppelin - The page is top notch. There’s nothing else to say, really. Top notch, indeed. Befitting of the band, wouldn’t you say?

Blue Island Tribe - It’s all waterworks here. And we have to admit, it looks pretty darn good. It may not be everyone’s cup of tea, but if you’re looking for surfer inspiration, you’ll be hard-pressed to find something much better.

Anouk - From top to bottom (or at least the middle), Anouk’s MySpace page is nicely finished. Everything is clearly delineated, which definitely works in its favor.

Kate Nash - It’s amazing what a checkerboard background can do to a MySpace page, isn’t it?

Citizen Cope - A grand banner topping the page, Citizen Cope’s profile has its rough spots, but there’s nothing that will displease. Chalk that assessment up to the backdrop.

Death Cab for Cutie - Have we gotten loose with our praise with this one? Perhaps, perhaps not. It’s certainly a subjective thing. Some will love the page for its squarish sensibility. It’s got a few abstract bones in its body, for sure.

Dido - Mostly black with plenty of beveled edges, Dido’s profile is well made. There’s ample empty space, which can detract from the sense of fine design, but that may suit some folks. Does it suit you?

Eisley - At least one member of the Mashable crew is partial to Eisley (hint: check the byline), so take this plug as you wish. The extra-large borders around every piece of the puzzle are what really bring things home.

Elbow - This band’s profile is black and white done right. It’s as simple as that.

Eminem - Everything’s so packed together that we can’t help but like it. It’s pretty much the antithesis of sprawl. Kudos on the set design, Eminem.

Ingrid Michaelson - There’s hardly anything unusual about this page, but its colorway and layout are what we think every band should strive for at the very least. The better to please listeners.

M.I.A. - Beware of the flash. Alternatively, if you like the flash, you’ll love it. Seriously.

Nine Inch Nails - Another fairly docile setup, the Nine Inch Nails profile is totally square and totally worth a plug. It’s NIN, through and through.

Radiohead - Its theme coincides with the In Rainbows release, so of course it looks great. Love the darkness, people. Love the darkness!

Smashing Pumpkins - How to summarize…. It has an elaborate headdress with plenty of band stamps to go around. Thumbs up for intelligent design.

U2 - Compared with the first half of this series, the U2 page is, in terms of the band’s global impression, woefully inadequate. But that’s this Irish quartet, for you. MySpace just isn’t cool enough for Bono and his Chanel shades. The thing is, the profile still amounts to an appreciable contribution to the network. How’s that for a finale?

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SpaceGravy Fills Up on MySpace Codes, MySpace Layouts and Backgrounds
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It’s a long road to a victory in the browser wars. Just ask Firefox. The open source browser which launched in 2004 just cracked the 20 percent threshold of the market share for November, according to Net Applications, pushing it a step closer but still miles away from IE.

Recently a few new players have also thrown their hats in the ring, including Google with its much-hyped Chrome and the lesser known, Mozilla-based social web browser Flock, which released its 2.0 version this past October. But do these newcomers even stand a chance?

The Basics

Firefox is gaining ground for good reason: it’s simple, reliable and secure. Its tabbed browsing led to a similar remodel in IE and it has a slew of add-ons that give it a leg up over the competition. It’s slowly becoming the new standard with a steady audience, and that will be hard to beat anytime soon. And its open source platform leaves room for alternatives and experimental niche browsers like Flock.

Flock 2.0 is basically a Firefox with a lot of perks and pre-installed add-ons for those heavy into social networking.  Think of it as a FriendFeed of the browser world, which brings all of your friends from 23 various networks together in a sidebar. It is also one of the first browsers to incorporate media feeds for photos and videos.  Flock is all about sharing what you find on the web as you surf, and it allows you to accomplish this pretty easily by dragging and dropping them either into an email or onto a friend.

Chrome is the polar opposite of Flock, and its big advantage is that it’s even simpler than Firefox, or any other browser out there right now.  The search bar is also integrated into the address bar, which seems to be the wave of the future, at least for those who swear by Google search and don’t need any bells and whistles. Unfortunately, Chrome’s only available for PCs at the moment.

Usability

Chrome wins hands down on getting the job done.  It’s quick and painless with a clear focus of searching for information using Google’s engine.  Dynamic tabbed browsing is a staple now, and if anything crashes, only that tab will go down, not your entire session, which is nice. But if you want a richer web browsing experience stick with Firefox or Flock.  There’s also no easy way to subscribe to RSS feeds from the search bar as there is with Firefox.

Flock can feel a bit overwhelming at times with all of the sidebars of information, but once you get everything set up and get the hang of it, it’s pretty convenient and preferable to keeping a million tabs open for sites like Twitter and Facebook. The drag and drop interface is great.  When you just want to email a YouTube video or picture it’s much easier than copying any URLs, although it does also seem a bit too easy to share something that you might not want shared.

The only other problem with the social networks is that you can’t really fit all of that functionality into a sidebar.  It’s a good way of consolidating friends, but it’s more like a giant address book than anything else. Simple things like posting tweets are a bit confusing, with no clear box for entering in text. When a friend adds content, however, it will open up the profile in the main browser in full view, so you still need to go back to the source.

Speed

Despite the extra features, Flock is surprisingly just as fast as Chrome or Firefox, at least on a medium grade PC.  Looks like they’ve improved upon this concern in the latest release. And Chrome seems to have Firefox beat in this category but the difference isn’t anything drastic.

Privacy

Incognito — aka “porn mode” –  is the new way to surf, as every browser is picking up on this private surfing option that Safari first initiated.

Chrome has faced some privacy concerns at launch with its Omnibox monitoring and recording too much information, but this can all be prevented by changing the default settings and going Incognito.

Expandability

Chrome doesn’t support any extensions or add-ons yet, so Firefox still dominates in this area.  But if you are looking for simple, you probably don’t want much more than Chrome already offers.

Final Thoughts

Firefox is here to stay, but there will always be a long tail of niche alternatives like Chrome and Flock.  When Chrome moves into Mac realm it could pick up some market share from Safari.  Flock will be there for social network junkies who want to try something new, but the first step to making Flock mainstream will be for more of the social networks themselves to go mainstream. Twitter is on track, but still has a long way to go before it’s a household name. If you’re only on Facebook or MySpace, you probably don’t need to worry about the extra sidebars and features.

---
Related Articles at Mashable | All That's New on the Web:

Flock Gets a New Boss, Flock 1.0 Coming
Flock Public Beta Now Live
How Can Flock’s Social Browser Play Into the “Open” Movement?
Flock’s Social Browser 1.0 Has Finally Arrived
More is More: Flock 2.0
Flock CEO Jumps Ship
Anxious About Private Browsing in Firefox? Try the Latest Build

Reading the come-on to prospective entrants provides some insight into the pressures biotech and pharma generally are facing these days to impress potential investors, analysts and the scientific community (from whence comes the brainpower it needs for survival’s sake):

“Take advantage of this opportunity to showcase your organization’s efforts and talents, and contribute to the industry’s broader knowledge base.

EARLY BIRD DEADLINE (No Fee): December 18, 2008
FINAL DEADLINE FOR ENTRIES: January 21, 2009

Benefits of participation:

* Gain Peer Recognition: Spotlight the talent of your team, and position your organization as a thought leader, among an elite group of life science professionals.
* Heighten Visibility: Use creative positioning to add another layer of credibility in the industry. Entries, nominees and especially winners receive recognition at the Gala Dinner, in widely-distributed press releases, in the Best Practices issue of Bio-IT World magazine, as well as continued coverage on Bio-ITWorld.com and in the Best Practices Compendium of entries.
* Leverage Exposure: Showcase your expertise and unique solutions, and use the exposure as a conduit to valuable connections, investors, sales leads, job candidates, and other external audiences.

Well, it is working with me so far!! I get the magazine and there is always something interesting about how modern science is conducted and the results disseminated.

It was interesting to read what fields are covered in competition:

* Basic Research & Biological Research: Disease pathway research, applied and basic research
* Drug Discovery & Development: Compound-focused research, drug safety
* Clinical Trials & Research: Trial design, eCTD
* Translational Medicine: Feedback loops, predictive technologies
* Personalized Medicine: Responders/non-responders, biomarkers
* IT & Informatics: LIMS, High Performance Computing, storage, data visualization, imaging technologies
* Knowledge Management: Data mining, idea/expertise mining, text mining, collaboration, resource optimization
* Health-IT: ePrescribing, RHIOs, EMR/PHR
* Manufacturing & Bioprocessing: Mass production, continuous manufacturing

I decided to take a look at what was showcased in 2008 and perusing many of the articles linked to is a good way to see how big pharma and big government science are adapting to the world of Science 2.0.

Here is an interesting article for example: Connecting the Cancer Community caBIG Time

Now this is an ambitious undertaking that I had not heard about before. Here is some of what I read here:

caBIG™ stands for the cancer Biomedical Informatics Grid™. caBIG™ is an information network enabling all constituencies in the cancer community – researchers, physicians, and patients – to share data and knowledge. The components of caBIG™ are widely applicable beyond cancer as well.

The mission of caBIG™ is to develop a truly collaborative information network that accelerates the discovery of new approaches for the detection, diagnosis, treatment, and prevention of cancer, ultimately improving patient outcomes.

The goals of caBIG™ are to:

* Connect scientists and practitioners through a shareable and interoperable infrastructure
* Develop standard rules and a common language to more easily share information
* Build or adapt tools for collecting, analyzing, integrating, and disseminating information associated with cancer research and care.

Since its inception, caBIG™ has committed to the following cornerstones:

* Federated: caBIG™ software and resources are widely distributed, interlinked, and available to everyone in the cancer research community, but institutions maintain local control over their own resources and data.
* Open-development: caBIG™ tools and infrastructure are being developed through an open, participatory process. caBIG™ leverages existing resources whenever possible, rather than building new tools in every case.
* Open-access:caBIG™ resources are freely obtainable by the cancer community to ensure broad data-sharing and collaboration.
* Open-source: The caBIG™ source code is available to view, alter, and redistribute.

Whoa! That is a pretty sweeping mandate and game plan! This is one heck of a gargantuan undertaking, but when you read about the dynamo behind it and look at how far it has come in a few years you start to have real faith in big government science and realize that within massive research organizations there are some damn impressive people who want to take a machete to stultifying processes and stodgy mindsets that have unnecessarily impeded scientific progress for too long. One such intellectual powerhouse is profiled thus:

Kenneth H. Buetow, Ph.D., is the National Cancer Institute (NCI) Associate Director for Bioinformatics and Information Technology and the Director of the NCI Center for Bioinformatics (NCICB). As Director of the NCICB, Dr. Buetow oversees coordination and deployment of informatics in support of NCI research initiatives and the Center’s participation in the evaluation and prioritization of the NCI’s biomedical informatics research portfolio. Dr. Buetow initiated the cancer Biomedical Informatics Grid™ (caBIG™) pilot project and oversees its activities.

Go, Dr. Buetow, go! Keep the good work! The hope, apparently, is to create a model in the case of cancer that will engender like networks throughout medicine. A worthy, noble goal.

By contrast, to the culture of openness Dr. Buetow exemplifies here is a case of really bad marketing. As I write this column, I am clicking around some of the links in the original Bio-IT World article. I wanted to see to check out what sorts of conferences were advertised for those in the biomedical field. I was rather intrigued by the idea of writing here about the 4th Annual World Healthcare Innovation and Technology Congress. But to get a brochure, you have to register — give me a break! How lame is that?

And then to compound the image of troglodyte thinking and the utter incapacity to grasp the revolution that is Web 2.0 that healthcare IT already has in the rest of the tech world, here is the wording on the press page.

“World Congress press credentials are available to full-time editorial staff writers employed by a trade publication, mainstream media outlet (newspaper, radio, TV, etc.), or online magazines. Freelance writers or contributing editors may request press credentials if the event is being covered for a specific publication.”

Grrrrrrrr. That pretty much excludes tech bloggers who produce some of the best coverage of IT around. If I were in charge of a major tech conference, I would not hire Patrick Golden to be my director of communications. But then I am just a little tech blogger and he has bigger fish to fry. But dissing the tech blogosphere is not the act of a smart person in the age of Web 2.0. No wonder the bright young minds of tech give healthcare a pass so very often–much to my continuing dismay, as someone who works in healthcare.